Professor MacLean obtained her Ph.D. in Pharmacology from the University of Edinburgh in 1985 and then spent a year in the USA and three years in Cambridge before moving to The University of Glasgow in 1989. She currently is Professor of Pulmonary Pharmacology at the University of Strathclyde. Her research over the last 25 years has focused on the role of serotonin in the development of pulmonary arterial hypertension (PAH). As more women get PAH than men, more recently her work has focused on sex effects and oestrogen metabolism in PAH. She recently won the 2017 Reynold Spector Award for Clinical Pharmacology from the American Society for Pharmacology and Experimental Therapeutics (ASPET). Other research awards include a Royal Society Wolfson Research Merit Award in 2010 and a Royal Society Leverhulme Trust Senior Research Fellowship in 2013. In 2013 she was elected as a Fellow of The Royal Society of Edinburgh (FRSE) and awarded the British Pharmacological Society AstraZeneca Prize for Women in Pharmacology. She was elected as an Ordinary Member and Trustee of Council for the Royal Society of Edinburgh and is now Vice-President (Life Sciences) of the Royal Society of Edinburgh. Mandy received an MBE in the 2010 Queen’s New Years Honours list for her career and public engagement activities. In 2018 she was made a Fellow of the Academy of Medical Sciences and has just been appointed the Scottish Champion for the Academy of Medical Sciences.